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Bioinformatics service for differential expression analysis of ribonucleic acid (RNA) sequencing data

Country of Origin: Spain
Reference Number: TOES20180424001
Publication Date: 24 April 2018

Summary

A Spanish biotechnological institute offers its bioinformatics service for the differential expression analysis of ribonucleic acid (RNA) sequencing data. The bioinformatics procedure involves quality control, alignment to reference genome, calculation of read counts per gene and differential expression analysis. Results would be provided with detail explanation of the output.
Both industrial and academic partners are sought for services agreements collaboration.

Description

The organization is a Spanish biotechnological private non-profit research institute, founded in 1993, whose main activities are related to molecular biology and microbial biotechnology. The institution keeps close links with industrial research and innovation. The team covers several techniques and counts with a long experience in scientific research in European funded projects.



The high-throughput ‘ribonucleic acid’ (RNA) sequencing (RNA-seq) allows the analysis of the transcriptome with great advantages over previous microarray technology, such as greater sensitivity, broader dynamic range and it can be applied to organisms without known genome sequence. Although these advantages, many laboratories might be reluctant to apply RNA-seq analyses to their investigations due to the complicated bioinformatics procedures that are needed to obtain significant data from the output of the sequencing machine.



These reads need to be processed by scientifically valid bioinformatics procedures as follows: quality control of the sequences, mapping of the reads on the reference genome, calculation for each annotated gene, the read counts per gen, normalization and differential expression analysis using a thoroughly-proven and well-established procedure. The last two steps are key to obtain significant results of the experiment. The bioinformatics service can provide the researchers with the results of the differential expression analysis, so they can focus in extracting relevant knowledge for their experiments.



The biotechnological institute is searching for academic and industrial partners in order to establish services agreements.

Advantages and Innovations

The competitive advantage of the institute lies in the experience of the researchers that provide this service is based on the common use of bioinformatics procedures, molecular microbiology and also in omics techniques. The team are involved as principal investigators of national and European projects. This broader experience serves to offer a service focused on the needs of the researchers and companies.

Stage Of Development

Already on the market

Requested partner

Biotech companies, academic research groups and any other organization interested in the study of transcriptomics (industrial microorganisms, model organisms and other) are sought in order to established a service agreement.