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Innovation & Technologie Angebot

New phytohormonal preparates for skin rejuvenation

Country of Origin: Czech Republic
Reference Number: TOCZ20170724002
Publication Date: 24 July 2017

Summary

Czech academic institution developed a new generation of cytokinins which have a very high anti-oxidant capacity and extend lifespan of C. elegans, a model organism frequently used in biogerontology research. License Agreement and research cooperation agreement is offered.

Description

Czech academic institution developed a new generation of cytokinins. This invention provides novel compounds with strong antioxidant activity, exceeding those of standard cosmetics (pyratine, retinol). These compounds can be formulated as anti‐aging, anti-acne rosacea and can be also used as eczema treatment. Novel compounds with strong antioxidant activity, exceeding those of standard active substances used in cosmetics (pyratine, retinol, ascorbic acid).

The compounds can be formulated as anti‐aging, anti‐rosacea and anti‐eczema cosmeceuticals or drugs. 

The technology needs to be licenced to some pharmaceutical or cosmetic company, with knowledge how to develop the technology and with possibly to get on market. The academic institution offers license agreement or research cooperation agreement.  

The research task is to find and test the possibilities of joining the new compound with a suitable cosmetic medium.

Advantages and Innovations

Phytohormones cytokinins promote cell division and delay senescence in plants. They have numerous beneficial effects

in humans as well ‐ cytoprotective, anti‐inflamatory and anti‐psoriatic activities were reported. Cytokinins including

Pyratine‐6 developed in our laboratory has been used as cosmeceuticals. 

A new generation of cytokinins which in contrast to the currently used ones have a very high anti‐oxidant capacity. They also extend lifespan of C. elegans, a model organism frequently used in biogerontology research. The compounds do not cause aberrant cell proliferation or apoptosis which are often side‐effects of other adenine‐based compounds.

Stage Of Development

Under development/lab tested

Stage Of Development Comment

Synthesis in the laboratory scale (>98%, NMR, HPLC‐MS, elemental). Experimental data on anti‐oxidant and anti‐aging aktivity. Preclinical characterization underway. Small clinical study underway.

Requested partner

License Agreement and reseach cooperation agreement is offered. Czech academic research institution is looking for research or business institution which would help to develop the product to clinical trial or get the substance to the market. They are able to provide information´s from preclinical phase.