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Microchannel integrated radio frequency MEMS (Micro-ElectroMechanical Systems) biosensor

Country of Origin: Turkey
Reference Number: TOTR20180612004
Publication Date: 12 June 2018

Summary

A Turkish researcher has developed an invention which relates to a mechanically robust, microwave biosensor fabricated using MEMS techniques for highly sensitive, rapid, label-free detection of biological or chemical substances. The biosensor subjected to this invention can be used for in-vitro, point-of-care diagnostics which can have wide range of applications covering environmental monitoring, drug-discovery, disease diagnosis etc.
The researcher looks for financial agreements

Description

In this invention by a Turkish researcher, in last decades, the field of biological and chemical sensors has gone through a significant growth, mainly due to the advancements in microfabrication technologies. The developed biosensors are mainly based on optical, mechanical and low-frequency electrochemical detection. Although they are quite effective, they have some drawbacks such as the use of optical markers.

Current detection systems are based on fluorescence methods such as enzyme-linked immunoabsorbent assay (ELISA) which use labels to detect the binding of biomarkers to a biorecognition element. These methods require heavy, expensive, optical devices and labeling of molecules. These bulky, costly and slow devices need a technical expert to operate and are not suitable for in-vitro, Point-of-Care diagnostics which can be used for environmental monitoring or drug-discovery applications.
In this invention, the microchannel and the co-planar waveguide structure is fabricated with a novel, integrative, sacrificial-free approach using flip-chip bonding. By this way, the fluid in the channel is to be employed as the dielectric material between the signal trace and the microchannel cap which connects the ground planes like a bridge. Thus, the signal is coupled to the ground through the fluid with a coupling coefficient. This coupling creates a capacitance which depends on the dielectric properties, and so the content of the fluid. Note that this coupling mainly occurs in the region where the cap and the signal overlap and the electromagnetic wave intensity is far higher here. Unlike many other devices in the literature, by the way of this invention the microchannel is integratedly fabricated into the RF (Radio Frequency) device which eliminates extra fabrication steps, reduces cost and improves the performance providing flexibility in the design of detection region.

The researcher has a spin off and is currently looking for financial agreements which will provide investment for his company.

Advantages and Innovations

The present invention differs from conventional methods in several ways.
Firstly, in this invention there is specific antibody-antigen binding event which provide the selectivity to the sensor. Thus, the sensors presented are not specific to the content of the fluid. That is, the change in the s-parameters may be due to different substances in the fluid. Secondly, by the way of this invention the sensitivity is enhanced by etching ground recesses instead of using periodic structures. This approach results in much simpler and cheaper sensitivity enhancement. Lastly, the fluid in this invention interacts only in high-dielectric-sensitive region owing to the fabrication method which provides less RF loss and ultra-high overall sensitivity.

Stage Of Development

Prototype available for demonstration

Requested partner

The researcher is offering the technological invention for financial agreements with repect to investment. The type of the partner sought can be industries related to chemicals,  molecular diagnosis, electronic engineering who looks for investment in a technological solution.

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