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Italian research group offers chemotherapy, a drug monitoring system for Imatinib and looking for financial agreement

Country of Origin: Italy
Reference Number: TOIT20200713001
Publication Date: 13 July 2020

Summary

An Italian research group has developed an electrochemical method to measure the concentration of the anti-cancer drug Imatinib in patient's plasma and then to establish the optimal dose, with an on-site test readable in real time. They are looking for financial agreement to facilitate the production of the prototype.

Description

The effectiveness of many anticancer drugs varies greatly from patient to patient, with risks of incorrect dosages and adverse side effects. The invention provides for the first time an electrochemical method to measure the concentration of the drug Imatinib, an anticancer drug used in particular for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. The therapeutic drug monitoring (TDM) greatly improves the effectiveness of the cancer treatment and helps to personalize the doses and to limit side effects. Quick procedures are therefore essential. The patented electrochemical method provides a simple, fast and cost-effective protocol for the measurement of Imatinib concentration through plasma collection; said method is suitable for the manufacturing of a device, that will make the test results readily and easily accessible at the patient's bed (point-of-care), avoiding long times required by specialized analysis. The method involves the selective extraction of the drug on a liquid-liquid extraction column and a following measurement of its concentration using an electrochemical technique, in particular adsorptive stripping voltammetry.
The system is under developement / lab tested and they are looking for partnerships with industry or investors in order to realize a prototype and go to market.

Advantages and Innovations

Simple protocol to be performed also by non-specialized personnel; rapid and accurate diagnosis on site; minimum amount of plasma required; results in real time; determination of drug concentration and therefore of treatment effectiveness for a timely adjustment of individual dosage.

Stage Of Development

Under development/lab tested

Stage Of Development Comment

The prototipe is under development in collaboration with a company specialized in the production of sensors.

Requested partner

They are looking for a financial partner to facilitate and speed up the production of the prototipe.

Cooperation offer ist closed for requests