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Circulating epithelial cells isolation in peripheral blood

Country of Origin: Spain
Reference Number: TOES20190424004
Publication Date: 24 April 2019


A Spanish research group of the public health system has developed a method of identifying circulating epithelial cells in peripheral blood to discriminate between patients with chronic obstructive pulmonary disease. The technology allows an earlier and more specific detection of the pulmonary disease than other current methods. 
A license agreement or a technical cooperation agreement for a public or private partnership for the further development of the patented technology is sought.


Chronic Obstructive Pulmonary Disease (COPD) is characterized by progressive airflow limitation and an inflammatory response in lungs.

The Spanish research group has developed a non-invasive, easily reproducible and specific technology of identifying circulating epithelial cells in peripheral blood

The use of liquid biopsy techniques to obtain epithelial cells, combined with immunological techniques for its detection, characterization and isolation, is useful for determining the patient's severity disease and for the early diagnosis of the disease.

The research group is looking for the following collaboration:
-License agreement: framework of authorizing the interested parts to use the technology.
-Technical cooperation agreement: to collaborate with other research teams, companies or foundations.

Advantages and Innovations

- This technology facilitates the personalized monitoring of each patient.

- The main advantage is based on the early and specific detection of chronic obstructive pulmonary disease, a major cause of morbidity and the third leading cause of death worldwide.

- It also allows the early diagnostic of the development of potential emphysema.

Stage Of Development

Prototype available for demonstration

Requested partner

The research group aims to formalize a technology transfer process with public or private entities interested in the implementation of the solution, through a license agreement. 

If there are some entities, such as R&D centres, technology centres or specialized companies, interested in collaborating and developing further aspects of the solution, a technical cooperation agreement could be envisaged.

They already sell the technology in Spain and now they want to expand abroad.

Cooperation offer ist closed for requests